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Polymorphisms of innate immunity genes influence disease progression in HIV-1-infected children

Freguja, Riccardoa; Gianesin, Kettya; Del Bianco, Paolab; Malacrida, Sandroc; Rampon, Osvaldad; Zanchetta, Marisab; Giaquinto, Carlod; De Rossi, Anitaa,b

doi: 10.1097/QAD.0b013e3283514350
Research Letters

Toll-like receptors (TLRs) and defensins (DEFs) play a crucial role in the host's innate immunity and may influence HIV-1 disease progression. We investigated the impact of TLR9 +1174G > A, 1635A > G and DEFβ1 −44C > G, −52G > A single nucleotide polymorphisms on the clinical outcome of 95 HIV-1-infected children. The TLR9 1635AG genotype and TLR9 [G;G] haplotype were associated with rapid disease progression, whereas the DEFβ1 −44CG genotype and DEFβ1 [G;G] haplotype correlated with a better clinical outcome.

aDepartment of Oncology and Surgical Sciences, AIDS Reference Centre, University of Padova

bIstituto Oncologico Veneto, IRCCS

cDepartment of Neurosciences

dDepartment of Pediatrics, University of Padova, Padua, Italy.

Correspondence to Anita De Rossi, Oncology Section, Department of Oncology and Surgical Science, AIDS Reference Centre, Via Gattamelata 64, 35128 Padua, Italy. E-mail:

Received 30 November, 2011

Revised 22 December, 2011

Accepted 10 January, 2012

© 2012 Lippincott Williams & Wilkins, Inc.