Institutional members access full text with Ovid®

Cross-species transmission of simian retroviruses: how and why they could lead to the emergence of new diseases in the human population

Locatelli, Sabrina; Peeters, Martine

doi: 10.1097/QAD.0b013e328350fb68
Editorial Review

The HIV-1 group M epidemic illustrates the extraordinary impact and consequences resulting from a single zoonotic transmission. Exposure to blood or other secretions of infected animals, through hunting and butchering of bushmeat, or through bites and scratches inflicted by pet nonhuman primates (NHPs), represent the most plausible source for human infection with simian immunodeficiency virus (SIV), simian T-cell lymphotropic virus (STLV) and simian foamy virus. The chance for cross-species transmissions could increase when frequency of exposure and retrovirus prevalence is high. According to the most recent data, human exposure to SIV or STLV appears heterogeneous across the African countries surveyed. Exposure is not sufficient to trigger disease: viral and host molecular characteristics and compatibility are fundamental factors to establish infection. A successful species jump is achieved when the pathogen becomes transmissible between individuals within the new host population. To spread efficiently, HIV likely required changes in human behavior. Given the increasing exposure to NHP pathogens through hunting and butchering, it is likely that SIV and other simian viruses are still transmitted to the human population. The behavioral and socio-economic context of the twenty-first century provides favorable conditions for the emergence and spread of new epidemics. Therefore, it is important to evaluate which retroviruses the human population is exposed to and to better understand how these viruses enter, infect, adapt and spread to its new host.

UMI 233, TransVIHMI, Institut de Recherche pour le Développement (IRD) and University of Montpellier 1, Montpellier, France.

Correspondence to Martine Peeters, UMI 233, TransVIHMI IRD, 911 Avenue Agropolis, BP 64501, 34394 Montpellier, Cedex 5, France. Tel: +33 4 6741 6161; fax: +33 4 6741 6146; e-mail: martine.peeters@ird.fr

Received 5 October, 2011

Revised 21 December, 2011

Accepted 3 January, 2012

© 2012 Lippincott Williams & Wilkins, Inc.