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Neurological manifestations of coinfection with HIV and human T-lymphotropic virus type 1

Silva, Marcus T.T.a; Neves, Elizabeth S.a; Grinsztejn, Beatrizc; de Melo Espíndola, Otáviob; Schor, Dorisb; Araújo, Abelardoa

doi: 10.1097/QAD.0b013e32834c4a3e
Research Letter

HIV-individuals are at risk for human T-lymphotropic virus (HTLV) coinfection and neurological diseases. Little is known about the impact of HAART among coinfected patients. In this study, 47 out of 428 HIV individuals were coinfected with HTLV (10.9%). Coinfection was an independent variable associated with neurological outcome (odds ratio 8.73). Coinfection was associated with myelopathy [chi square (X2) = 93, P < 0.001], peripheral neuropathy (X2 = 6.5, P = 0.01), and hepatitis C virus infection (X2 = 36.5, P < 0.001). HAART did not appear to protect against neurological diseases and had no impact on HTLV proviral load.

aLaboratório de Pesquisa Clínica em Neuroinfecção

bLaboratório de Pesquisa em Patogenia Viral

cLaboratório de Pesquisa Clínica em DST/AIDS, Instituto de Pesquisa Clínica Evandro Chagas (IPEC), Fundação Oswaldo Cruz (FIOCRUZ), Rio de Janeiro, Brazil.

Correspondence to Marcus Tulius T. Silva, MD, PhD, IPEC/FIOCRUZ, Laboratório de Pesquisa Clínica em Neuroinfecção, Avenida Brasil, 4365 – Rio de Janeiro, CEP 21040-360, Brazil. Fax: +55 21 26102921.e-mail:

Received 9 February, 2011

Revised 9 August, 2011

Accepted 24 August, 2011

This study was sponsored by the Programa Nacional DST/AIDS do Ministério da Saúde, Fundação Oswaldo Cruz (FIOCRUZ), and Conselho Nacional de Desenvolvimento Científico e Tecnológico – Programa Bolsa de Produtividade em Pesquisa (CNPq).

© 2012 Lippincott Williams & Wilkins, Inc.