HIV-individuals are at risk for human T-lymphotropic virus (HTLV) coinfection and neurological diseases. Little is known about the impact of HAART among coinfected patients. In this study, 47 out of 428 HIV individuals were coinfected with HTLV (10.9%). Coinfection was an independent variable associated with neurological outcome (odds ratio 8.73). Coinfection was associated with myelopathy [chi square (X2) = 93, P < 0.001], peripheral neuropathy (X2 = 6.5, P = 0.01), and hepatitis C virus infection (X2 = 36.5, P < 0.001). HAART did not appear to protect against neurological diseases and had no impact on HTLV proviral load.
aLaboratório de Pesquisa Clínica em Neuroinfecção
bLaboratório de Pesquisa em Patogenia Viral
cLaboratório de Pesquisa Clínica em DST/AIDS, Instituto de Pesquisa Clínica Evandro Chagas (IPEC), Fundação Oswaldo Cruz (FIOCRUZ), Rio de Janeiro, Brazil.
Correspondence to Marcus Tulius T. Silva, MD, PhD, IPEC/FIOCRUZ, Laboratório de Pesquisa Clínica em Neuroinfecção, Avenida Brasil, 4365 – Rio de Janeiro, CEP 21040-360, Brazil. Fax: +55 21 26102921.e-mail: email@example.com
Received 9 February, 2011
Revised 9 August, 2011
Accepted 24 August, 2011
This study was sponsored by the Programa Nacional DST/AIDS do Ministério da Saúde, Fundação Oswaldo Cruz (FIOCRUZ), and Conselho Nacional de Desenvolvimento Científico e Tecnológico – Programa Bolsa de Produtividade em Pesquisa (CNPq).