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Anogenital pseudotumoral herpes and HIV infection: a new challenge for diagnosis and treatment

Di Lucca-Christment, Juliea,*; Jacobelli, Simona; Gressier, Ludiviena; Plantier, Françoiseb; Laude, Hélènec,d; Rosenberg, Florec,d; Morini, Jean-Pierrea; Dallot, Alexianee; Avril, Marie-Françoisea; Dupin, Nicolasa,d

doi: 10.1097/QAD.0b013e32835049be
Research Letter

HIV-infected patients may develop rare anogenital pseudotumoral herpes potentially mimicking epidermoid carcinoma. We assessed treatment in five new cases with a median follow-up of 3.3 years. Recurrence and clinical nucleoside analog resistance were observed in all patients. All drug treatments were only temporarily curative and clinical responses varied between patients and recurrences. Foscavir seemed to be the most appropriate second-line treatment and cidofovir or thalidomide should be considered as alternative treatments.

aDermatology Department

bPathology Department

cVirology Department of Cochin Hospital, APHP

dUPRES EA 1833, René Descartes University Faculty of Medicine, Paris

eRobert Ballanger Hospital, Aulnay sous Bois, Paris, France.

*Present address: Dermatology Unit, Hospital Bichat, APHP, Paris, France.

Correspondence to Nicolas Dupin, Service de Dermatologie, Hôpital Cochin, APHP, Pavillon Tarnier, 89 rue d’Assas, 75006 Paris, France. Tel: +33 158 411 813; fax: +33 158 411 765; e-mail:

Received 29 August, 2011

Revised 9 November, 2011

Accepted 12 December, 2011

© 2012 Lippincott Williams & Wilkins, Inc.