Skip Navigation LinksHome > March 13, 2011 - Volume 25 - Issue 5 > Global trends in molecular epidemiology of HIV-1 during 2000...
doi: 10.1097/QAD.0b013e328342ff93
Epidemiology and Social

Global trends in molecular epidemiology of HIV-1 during 2000–2007

Hemelaar, Jorisa; Gouws, Eleanorb; Ghys, Peter Db; Osmanov, Saladinc; WHO-UNAIDS Network for HIV Isolation and Characterisation

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Objective: To estimate the global and regional distribution of HIV-1 subtypes and recombinants between 2000 and 2007.

Design: Country-specific HIV-1 molecular epidemiology data were combined with estimates of the number of HIV-infected people in each country.

Methods: Cross-sectional HIV-1 subtyping data were collected from 65 913 samples in 109 countries between 2000 and 2007. The distribution of HIV-1 subtypes in individual countries was weighted according to the number of HIV-infected people in each country to generate estimates of regional and global HIV-1 subtype distribution for the periods 2000–2003 and 2004–2007.

Results: Analysis of the global distribution of HIV-1 subtypes and recombinants in the two periods indicated a broadly stable distribution of HIV-1 subtypes worldwide with a notable increase in the proportion of circulating recombinant forms (CRFs), a decrease in unique recombinant forms (URFs) and an overall increase in recombinants. In 2004–2007, subtype C accounted for nearly half (48%) of all global infections, followed by subtypes A (12%) and B (11%), CRF02_AG (8%), CRF01_AE (5%), subtype G (5%) and D (2%). Subtypes F, H, J and K together cause fewer than 1% of infections worldwide. Other CRFs and URFs are each responsible for 4% of global infections, bringing the combined total of worldwide CRFs to 16% and all recombinants (CRFs along with URFs) to 20%.

Conclusion: The global and regional distributions of individual subtypes and recombinants are broadly stable, although CRFs may play an increasing role in the HIV pandemic. The global diversity of HIV-1 poses a formidable challenge to HIV vaccine development.

© 2011 Lippincott Williams & Wilkins, Inc.


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