AIDS

Skip Navigation LinksHome > January 14, 2011 - Volume 25 - Issue 2 > Serological immunity to adenovirus serotype 5 is not associa...
AIDS:
doi: 10.1097/QAD.0b013e328342115c
Basic Science

Serological immunity to adenovirus serotype 5 is not associated with risk of HIV infection: a case–control study

Curlin, Marcel Ea,b; Cassis-Ghavami, Faraha; Magaret, Amalia Sa,c; Spies, Gregory Aa; Duerr, Anna; Celum, Connie Lb,d,e; Sanchez, Jorge Lf; Margolick, Joseph Bg; Detels, Rogerh; McElrath, M Julianaa,b,e; Corey, Lawrencea,b,c

Collapse Box

Abstract

Background: Adenoviruses are among the most promising vectors for the development of an HIV vaccine. The results of the phase IIB study of the adenovirus serotype 5-based Merck Trivalent HIV vaccine have raised the concern that serological immunity to adenovirus serotype 5 (Ad5) could be linked to HIV acquisition risk in high-risk individuals. We examined the association between adenovirus serostatus and the rate of incident HIV infection in populations at elevated risk of HIV acquisition.

Methods: We performed a nested case–control study of Ad5 serostatus among 299 HIV-infected and 590 matched HIV-uninfected persons participating in the Multicenter AIDS Cohort Study (MACS) and in HPTN 039, a study of herpes simplex virus 2 suppression among adults in the United States, South America, and Africa. Appropriate HIV cases and controls were identified in each cohort, and Ad5-neutralizing antibody titers were compared in these two groups.

Results: In MACS and HPTN 039, the relative risks of incident HIV infection among Ad5-seropositive vs. Ad5-seronegative individuals were 1.1 (95% confidence interval 0.8–1.5, P = 0.57) and 1.0 (95% confidence interval 0.4–2.3, P = 0.99), respectively. HIV-1 acquisition rates did not vary significantly by Ad5-neutralizing antibody titer.

Conclusion: The presence of Ad5-neutralizing antibodies is not linked to the risk of HIV acquisition among populations at elevated risk of HIV infection.

© 2011 Lippincott Williams & Wilkins, Inc.

Login

Article Tools

Share

Article Level Metrics

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.