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Skip Navigation LinksHome > January 14, 2011 - Volume 25 - Issue 2 > Interleukin-28B gene polymorphisms do not influence the susc...
AIDS:
doi: 10.1097/QAD.0b013e328341b84e
Research Letters

Interleukin-28B gene polymorphisms do not influence the susceptibility to HIV-infection or CD4 cell decline

Rallon, Norma Ia; Restrepo, Claraa; Naggie, Susannab; Lopez, Mariolaa; del Romero, Jorgec; Goldstein, Davidd; McHutchison, Johnb; Soriano, Vincenta; Benito, Jose Ma

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Abstract

The critical role of interleukin-28B (IL28B)/interferon-λ3 (IFN-λ3) polymorphisms on the susceptibility to hepatitis C virus infection and the response to peginterferon–ribavirin therapy has encouraged exploration of similar effects on other viruses. Given that IFN-λ mediates anti-HIV-1 activity, the protective role of IL28B polymorphisms was examined in 29 seronegative individuals at risk for HIV-infection and in 68 HIV-positive carriers with and without rapid progression of immunodeficiency. No protective role of IL28B polymorphism was found examining both HIV-disease progression and HIV-protection.

© 2011 Lippincott Williams & Wilkins, Inc.

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