Pandemic influenza A (H1N1) in HIV-1-infected patients

Perez, Carlos Ma; Dominguez, Maria Ia; Ceballos, Maria Ea; Moreno, Cristinaa; Labarca, Jaime Aa; Rabagliati, Ricardoa; Vasquez, Patriciab; Lasso, Martinc; Serri, Micheld

doi: 10.1097/QAD.0b013e32833e92d5
Epidemiology and Social: Concise Communications

Objective: To characterize the clinical presentation, course and mortality of pandemic influenza in HIV-1-infected patients in Santiago, Chile.

Methods: Prospective observational study.

Results: Thirty patients were included (three hospitalized), 93% were on HAART, mean CD4+ cell count was 423 cells/μl and viral load was undetectable in 77% of patients. All patients had fever, 90% had cough, 80% had myalgias, 70% had pharyngeal congestion, 47% had coryza, 47% had odynophagia, 37% had headache and 23% had vomiting. Four patients developed pneumonia. All patients received antiviral therapy and no patient died.

Conclusions: HIV patients infected by the new influenza A pandemic (H1N1) virus behave similarly to the general population.

aDepartment of Medicine, School of Medicine, Pontificia Universidad Católica de Chile

bDepartment of Medicine, Hospital San Juan de Dios y Clínica Dávila, Chile

cDepartment of Medicine, Hospital Sótero del Río, Chile

dDepartment of Medicine, Hospital FACH, Santiago, Chile.

Received 12 March, 2010

Revised 11 July, 2010

Accepted 21 July, 2010

Correspondence to Carlos M. Perez, MD, Department of Medicine, School of Medicine, Pontificia Universidad Católica de Chile, Marcoleta 357, Santiago, Chile. E-mail: cape@med.puc.cl

© 2010 Lippincott Williams & Wilkins, Inc.