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Virosomal influenza-vaccine induced immunity in HIV-infected individuals with high versus low CD4+ T-cell counts: clues towards a rational vaccination strategy

Fritz, Stefaniea,*; Mossdorf, Erikb,*; Durovic, Bojanaa; Zenhaeusern, Gabrielaa; Conen, Annab; Steffen, Ingridd; Battegay, Manuelb; Nüesch, Retob; Hess, Christopha,c

doi: 10.1097/QAD.0b013e32833c6f92
Research Letters

In a prospective influenza-vaccination trial we show that HIV-infected individuals with CD4+ T-cell counts less than 350 μl were distinct from HIV-infected individuals with more than 350 CD4+ T-cell counts/μl, and from HIV-negative individuals, in that an influenza-specific immunoglobulin M-response was absent and expansion of interferon-γ-secreting CD4+ T cells was impaired. By contrast, immunoglobulin G-responses were induced in all study groups. These data suggest that establishing broad influenza-specific (immunoglobulin G) B-cell memory prior to severe immunodeficiency is important.

aImmunobiology Laboratory, Department of Biomedicine, Basel University, Switzerland

bDivision of Infectious Diseases and Hospital Epidemiology, Switzerland

cMedical Outpatient Department, University Hospital Basel, Switzerland

dInstitute for Medical Microbiology, Basel University, Basel, Switzerland.

*S.F. and E.M. contributed equally to this work.

Received 11 March, 2010

Revised 30 April, 2010

Accepted 24 May, 2010

Correspondence to Christoph Hess, MD, PhD, Medical Outpatient Department and Department of Biomedicine, University Hospital Basel, 4 Petersgraben, CH-4031 Basel, Switzerland. Tel: +41 61 265 44 75; e-mail: chess@uhbs.ch

© 2010 Lippincott Williams & Wilkins, Inc.