Skip Navigation LinksHome > August 24, 2010 - Volume 24 - Issue 13 > The cytotoxic lymphocyte antigen 4 polymorphisms affect resp...
doi: 10.1097/QAD.0b013e32833bedc8
Basic Science: Concise Communication

The cytotoxic lymphocyte antigen 4 polymorphisms affect response to hepatitis C virus-specific therapy in HIV(+) patients with acute and chronic hepatitis C virus co-infection

Nischalke, Hans Dietera; Vogel, Martina; Mauss, Stefanb; Baumgarten, Axelc; Lutz, Thomasd; Danta, Marcf; Naumann, Uwee; Coenen, Martina; Sauerbruch, Tilmana; Rockstroh, Jürgen Ka; Spengler, Ulricha; Nattermann, Jacoba

Collapse Box


Objective: Cytotoxic lymphocyte antigen 4 (CTLA4), a co-receptor expressed on T lymphocytes, is involved in the regulation of T-cell functions. Here, we analyzed the potential impact of the CTLA4 polymorphisms on response to hepatitis C virus (HCV)-specific treatment in HIV(+) patients co-infected with HCV.

Patients and methods: A total of 184 HIV/HCV co-infected Caucasian patients were enrolled into this study, including 109 patients with chronic and 75 patients with acute hepatitis C. CTLA4 genotypes were determined by LightCycler PCR.

Results: We found the CTLA4 −318 C/C genotype to be associated with sustained virological response in HCV/HIV co-infection (P = 0.035). Moreover, response rates were significantly higher in patients with a +49G/G genotype [23/29 (79.3%)] than in carriers of other +49 genotypes [59/155 (38.1%); OR 6.2; P = 0.00005]. Of note, the CTLA4 +49G/G genotype was confirmed as an independent predictor for treatment response in both patients with acute and chronic hepatitis C.

Conclusion: CTLA4 polymorphisms are associated with treatment-induced resolution of HCV infection in HIV co-infected patients. These findings underline the impact of genetic host factors for successful treatment.

© 2010 Lippincott Williams & Wilkins, Inc.


Article Tools


Article Level Metrics

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.