Institutional members access full text with Ovid®

Epidemiology of HIV infection in the Middle East and North Africa

Abu-Raddad, Laith Ja,b,c; Hilmi, Nahlad; Mumtaz, Ghinaa; Benkirane, Manale; Akala, Francisca Ayodejid; Riedner, Gabrielef; Tawil, Oussamag; Wilson, Davidh

doi: 10.1097/01.aids.0000386729.56683.33
Article

Objective: The Middle East and North Africa (MENA) region continues to be perceived as a region with very limited HIV epidemiological data, raising many controversies about the status of the epidemic in this part of the world. The objective of this review and synthesis was to address the dearth of strategic interpretable data on HIV in MENA by delineating a data-driven overview of HIV epidemiology in this region.

Methods: A comprehensive systematic review of HIV, sexually transmitted infections (STIs) and risk behavior studies in MENA, irrespective of design, was undertaken. Sources of data included Medline for peer-reviewed publications, Google Scholar for other scientific literature published in nonindexed local and regional journals, international organizations reports and databases, country-level reports and database including governmental and nongovernmental organizations publications, as well as various other institutional documents.

Results: Over 5000 sources of data related to HIV and STIs were identified and reviewed. The quality of data and nature of study designs varied substantially. There was no evidence for a sustainable HIV epidemic in the general population in any of the MENA countries, except possibly for southern Sudan. The general pattern in different countries in MENA points towards emerging epidemics in high-risk populations including injecting drug users, men who have sex with men (MSM) and to a lesser extent female sex workers, with heterogeneity between countries on the relative role of each of these high-risk groups. Exogenous HIV exposures among nationals linked to travel abroad appeared to be the dominant HIV transmission pattern in a few MENA countries with no evidence for much epidemic or endemic transmission. The role of bridging populations in bridging the HIV infection to the general population was found to be very limited.

Conclusion: Although they do not provide complete protection against HIV spread, near universal male circumcision and possibly the prevailing sexually conservative cultural norms seemed to have played so far a protective role in slowing and limiting HIV transmission in MENA relative to other regions. If the existing social and epidemiological context remains largely the same, HIV epidemic transmission is likely to remain confined to high-risk populations and their sexual partners, in addition to exogenous exposures. HIV prevention efforts in this region, which continue to be stymied by stigma associated with HIV/AIDS and related risk behaviors, need to be aggressively expanded with a focus on controlling HIV spread along the contours of risk and vulnerability. There is still a window of opportunity to control further HIV transmission among high-risk groups in MENA that, if missed, may entail a health and socioeconomic burden that the region, in large part, is unprepared for.

aWeill Cornell Medical College – Qatar, Cornell University, Qatar Foundation - Education City, Doha, Qatar

bDepartment of Public Health, Weill Cornell Medical College, Cornell University, New York, New York, USA

cVaccine and Infectious Disease Institute, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA

dHuman Development Sector, Middle East and North Africa Region, World Bank, District of Columbia, USA

eAssociation de Lutte Contre le Sida, Marrakesh, Morocco, Egypt

fRegional Office of the Eastern Mediterranean, World Health Organization, Egypt

gJoint United Nations Programme on HIV/AIDS Regional Support Team, Middle East and North Africa, Cairo, Egypt

hGlobal HIV/AIDS Program, World Bank, Washington, District of Columbia, USA.

Correspondence to Laith J. Abu-Raddad, PhD, Weill Cornell Medical College – Qatar, Qatar Foundation – Education City, P.O. Box 24144, Doha, Qatar. Tel: +974 492 8321; fax: +974 492 8333; e-mail: lja2002@qatar-med.cornell.edu

© 2010 Lippincott Williams & Wilkins, Inc.