Seronegative HIV-1 infection: a review of the literature

Spivak, Adam M; Sydnor, Emily RM; Blankson, Joel N; Gallant, Joel E

doi: 10.1097/QAD.0b013e32833ac65c
Basic Science

HIV-1-specific antibodies can be detected in HIV-1-positive patients within weeks of primary infection. Rare cases have been reported of patients who are persistently seronegative despite evidence of HIV-1 infection. We present a retrospective review of the clinical, virologic and immunologic characteristics of 25 persistently seronegative patients whose cases have been published to date and postulate a biologic mechanism for this phenomenon.

Johns Hopkins School of Medicine, Division of Infectious Diseases, Baltimore, Maryland, USA.

Received 6 January, 2010

Revised 23 March, 2010

Accepted 8 April, 2010

Correspondence to Dr Joel E. Gallant, Johns Hopkins School of Medicine, Division of Infectious Diseases, 1830 East Monument Street, 4th floor, Baltimore, MD 21287, USA. Tel: +1 410 955 7473; e-mail: jgallant@jhmi.edu

© 2010 Lippincott Williams & Wilkins, Inc.