Skip Navigation LinksHome > June 19, 2010 - Volume 24 - Issue 10 > Seronegative HIV-1 infection: a review of the literature
doi: 10.1097/QAD.0b013e32833ac65c
Basic Science

Seronegative HIV-1 infection: a review of the literature

Spivak, Adam M; Sydnor, Emily RM; Blankson, Joel N; Gallant, Joel E

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HIV-1-specific antibodies can be detected in HIV-1-positive patients within weeks of primary infection. Rare cases have been reported of patients who are persistently seronegative despite evidence of HIV-1 infection. We present a retrospective review of the clinical, virologic and immunologic characteristics of 25 persistently seronegative patients whose cases have been published to date and postulate a biologic mechanism for this phenomenon.

© 2010 Lippincott Williams & Wilkins, Inc.


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