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Long-term immunovirologic control following antiretroviral therapy interruption in patients treated at the time of primary HIV-1 infection

Hocqueloux, Laurenta; Prazuck, Thierrya; Avettand-Fenoel, Véroniqueb,c; Lafeuillade, Alaind; Cardon, Bernarde; Viard, Jean-Paulc,f; Rouzioux, Christineb,c

doi: 10.1097/QAD.0b013e32833b61ba
Research Letters

Five out of 32 patients who received very early and prolonged antiretroviral therapy displayed an unusual, sustained immunovirological control after treatment discontinuation (mean duration: 77 months). These ‘post-treatment controllers’ did not have the genetic characteristics of spontaneous ‘elite’ controllers, although they shared very low and stable level of viral reservoir. Treatment may have dramatically decreased this reservoir and preserved potent HIV-specific immunologic responses, inducing a new balance between the virus and the host's immune system in these patients.

aService de Maladies Infectieuses et Tropicales, Centre Hospitalier Régional, Orléans, France

bLaboratoire de Virologie, APHP, Hôpital Necker-Enfants Malades, France

cEA 3620, Université Paris Descartes, Paris, France

dService de Maladies Infectieuses et Tropicales, Hôpital Font Pré, Toulon, France

eService de Maladies Infectieuses et Tropicales, Hôpital Tenon, France

fService de Maladies Infectieuses et Tropicales, Hôpital Necker-Enfants Malades, Paris, France.

Received 14 February, 2010

Revised 20 April, 2010

Accepted 24 April, 2010

Correspondence to Dr Laurent Hocqueloux, Service de Maladies Infectieuses et Tropicales, CHR d'Orléans – La Source, BP 86709, 45067 Orléans Cedex 2, France. Tel: +33 2382 29588; fax: +33 2385 14153; e-mail: laurent.hocqueloux@chr-orleans.fr

© 2010 Lippincott Williams & Wilkins, Inc.