A newly described cytokine, interleukin-27 (IL-27), that activates naive CD4 T cells, has recently been shown to be an anti-HIV cytokine. However, the effect of HIV infection on IL-27 expression has not been characterized. We found that clinical characteristics, including HIV viral load, hepatitis C virus coinfection, and CD4 T cell counts, were associated with changes in serum IL-27. Overall, our results suggest circulating HIV may suppress IL-27, a critical concept in treatment development with this cytokine.
aDepartment of Microbiology and Immunology, Canada
bDepartment of Community Health and Epidemiology, Canada
cDivision of Infectious Disease, Department of Medicine, Queen's University, Kingston, Ontario, Canada.
Received 30 December, 2009
Revised 15 February, 2010
Accepted 25 February, 2010
Correspondence to Katrina Gee, Department of Microbiology and Immunology, Queen's University, Rm 738 Botterell Hall, Kingston, ON K7L3N6, Canada. E-mail: kgee@queensu,ca