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Impact of HIV infection, highly active antiretroviral therapy, and hepatitis C coinfection on serum interleukin-27

Guzzo, Christinaa; Hopman, Wilma Mb; Mat, Nor Fazila Chea; Wobeser, Wendyc; Gee, Katrinaa

doi: 10.1097/QAD.0b013e3283391d2b
Research Letters

A newly described cytokine, interleukin-27 (IL-27), that activates naive CD4 T cells, has recently been shown to be an anti-HIV cytokine. However, the effect of HIV infection on IL-27 expression has not been characterized. We found that clinical characteristics, including HIV viral load, hepatitis C virus coinfection, and CD4 T cell counts, were associated with changes in serum IL-27. Overall, our results suggest circulating HIV may suppress IL-27, a critical concept in treatment development with this cytokine.

aDepartment of Microbiology and Immunology, Canada

bDepartment of Community Health and Epidemiology, Canada

cDivision of Infectious Disease, Department of Medicine, Queen's University, Kingston, Ontario, Canada.

Received 30 December, 2009

Revised 15 February, 2010

Accepted 25 February, 2010

Correspondence to Katrina Gee, Department of Microbiology and Immunology, Queen's University, Rm 738 Botterell Hall, Kingston, ON K7L3N6, Canada. E-mail: kgee@queensu,ca

© 2010 Lippincott Williams & Wilkins, Inc.