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No evidence for a polyomavirus association or aetiology in AIDS-associated nonsmall cell lung cancer

Stebbing, Justina; Wickenden, Colina; Castellano, Leandroa; Sita-Lumsden, Ailsab; Nelson, Markb; Jacob, Jimmya; Naresh, Kikeric; Mauri, Francescoc; Bower, Markb

doi: 10.1097/QAD.0b013e3283383ac9
Research Letters

AIDS-associated lung cancer has an increasing incidence, unaccounted for by smoking, and occurs consistently at a younger age than matched controls. We investigated whether known and new cancer-associated polyomaviruses, including the newly identified Merkel cell virus, may play a role in its etiopathogenesis. Although viruses target conserved pathways in cellular evolution, we are unable to suggest that the viruses studied here induce novel mechanisms of oncogenic dysregulation in AIDS-associated lung cancer.

aDepartment of Oncology, Imperial College, Hammersmith Hospital, UK

bDepartment of HIV Medicine and Oncology, Imperial College, Chelsea and Westminster Hospital, UK

cDepartment of Pathology, Imperial College, Hammersmith Hospital, London, UK.

Received 24 November, 2009

Revised 31 January, 2010

Accepted 1 February, 2010

Correspondence to Justin Stebbing, MA, MRCP, FRCPath, PhD, Division of Surgery, Oncology, Reproductive Medicine and Anaesthesia, Imperial College School of Medicine, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK. E-mail: j.stebbing@imperial.ac.uk

© 2010 Lippincott Williams & Wilkins, Inc.