AIDS

Skip Navigation LinksHome > May 15, 2010 - Volume 24 - Issue 8 > No evidence for a polyomavirus association or aetiology in A...
AIDS:
doi: 10.1097/QAD.0b013e3283383ac9
Research Letters

No evidence for a polyomavirus association or aetiology in AIDS-associated nonsmall cell lung cancer

Stebbing, Justina; Wickenden, Colina; Castellano, Leandroa; Sita-Lumsden, Ailsab; Nelson, Markb; Jacob, Jimmya; Naresh, Kikeric; Mauri, Francescoc; Bower, Markb

Collapse Box

Abstract

AIDS-associated lung cancer has an increasing incidence, unaccounted for by smoking, and occurs consistently at a younger age than matched controls. We investigated whether known and new cancer-associated polyomaviruses, including the newly identified Merkel cell virus, may play a role in its etiopathogenesis. Although viruses target conserved pathways in cellular evolution, we are unable to suggest that the viruses studied here induce novel mechanisms of oncogenic dysregulation in AIDS-associated lung cancer.

© 2010 Lippincott Williams & Wilkins, Inc.

Login

Article Level Metrics