Skip Navigation LinksHome > January 2, 2010 - Volume 24 - Issue 1 > Illness during pregnancy and bacterial vaginosis are associa...
doi: 10.1097/QAD.0b013e32832326d8
Research Letters

Illness during pregnancy and bacterial vaginosis are associated with in-utero HIV-1 transmission

Farquhar, Careya,b; Mbori-Ngacha, Dorothyc; Overbaugh, Julied; Wamalwa, Daltonc; Harris, Jennifera; Bosire, Rosee; John-Stewart, Gracea,b

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HIV-1 transmission in utero accounts for 20–30% of vertical transmission events in breast-feeding populations. In a prospective study of 463 HIV-1-infected mothers and infants, illness during pregnancy was associated with 2.6-fold increased risk of in-utero HIV-1 transmission [95% confidence interval (CI) 1.2–5.8] and bacterial vaginosis with a three-fold increase (95% CI 1.0–7.0) after adjusting for maternal HIV-1 viral load. Interventions targeting these novel risk factors could lead to more effective prevention of transmission during pregnancy.

© 2010 Lippincott Williams & Wilkins, Inc.


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