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A polymorphism in the HCP5 gene associated with HLA-B*5701 does not restrict HIV-1 in vitro

Yoon, Woohyuna; Ma, Ben-Jiangb; Fellay, Jacquesa; Huang, Weia; Xia, Shi-Maob; Zhang, Ruijunb; Shianna, Kevin Vc; Liao, Hua-Xinb; Haynes, Barton Fb; Goldstein, David Ba; the NIAID Center for HIV/AIDS Vaccine Immunology

doi: 10.1097/QAD.0b013e32833202f5
Research Letters

A single-nucleotide polymorphism (rs2395029) in the HCP5 gene associated with HLA-B*5701 is correlated with lower HIV-1 viral set point. The two allelic forms of coding region were ectopically expressed in TZM-bl cells for an effect on HIV-1 replication. No significant HIV-1 restriction was observed in the cells with infectivity assays throughout HIV-1 life cycle, suggesting that the association of HCP5 variant with viral control is likely due to HLA-B*5701-related effect or other functional variants in the haplotype or both.

aCenter for Human Genome Variation, Duke Institute for Genome Sciences and Policy, USA

bDuke Human Vaccine Institute, USA

cDuke Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina, USA.

Received 29 July, 2009

Revised 13 August, 2009

Accepted 18 August, 2009

© 2010 Lippincott Williams & Wilkins, Inc.