A single-nucleotide polymorphism (rs2395029) in the HCP5 gene associated with HLA-B*5701 is correlated with lower HIV-1 viral set point. The two allelic forms of coding region were ectopically expressed in TZM-bl cells for an effect on HIV-1 replication. No significant HIV-1 restriction was observed in the cells with infectivity assays throughout HIV-1 life cycle, suggesting that the association of HCP5 variant with viral control is likely due to HLA-B*5701-related effect or other functional variants in the haplotype or both.
aCenter for Human Genome Variation, Duke Institute for Genome Sciences and Policy, USA
bDuke Human Vaccine Institute, USA
cDuke Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina, USA.
Received 29 July, 2009
Revised 13 August, 2009
Accepted 18 August, 2009