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Rapid clinical progression to AIDS and death in a persistently seronegative HIV-1 infected heterosexual young man

Bártolo, Inêsa,b; Camacho, Ricardoc,d; Barroso, Helenaa,b; Bezerra, Victore; Taveira, Nunoa,b

doi: 10.1097/QAD.0b013e328332d5e1
Research Letters

Seronegative HIV-1 infection has important implications for diagnosis and prevention. We describe a case of HIV-1 infection without seroconversion and fast progression to AIDS and death. Genetic and phylogenetic analysis indicated that the patient was infected with a CRF14_BG-like strain selectively transmitted by his seropositive sexual partner. The results suggest a massive infection with a highly aggressive CRF14_BG-like strain and/or the presence of an unidentified immunological deficiency that has prevented the formation of HIV-1-specific antibodies.

aUnidade dos Retrovírus e Infecções Associadas, Centro de Patogénese Molecular, Faculdade de Farmácia de Lisboa, Lisbon, Portugal

bCentro de Investigação Interdisciplinar Egas Moniz (CiiEM), Instituto Superior de Ciências da Saúde Sul, Caparica, Portugal

cLaboratório de Biologia Molecular, Centro Hospitalar Lisboa Ocidental, Lisboa, Portugal

dInstituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Lisboa, Portugal

eServiço de Medicina 1, Hospital Distrital de Santarém, Santarém, Portugal.

Received 30 July, 2009

Revised 2 September, 2009

Accepted 9 September, 2009

© 2009 Lippincott Williams & Wilkins, Inc.