Skip Navigation LinksHome > November 13, 2009 - Volume 23 - Issue 17 > Rapid clinical progression to AIDS and death in a persistent...
doi: 10.1097/QAD.0b013e328332d5e1
Research Letters

Rapid clinical progression to AIDS and death in a persistently seronegative HIV-1 infected heterosexual young man

Bártolo, Inêsa,b; Camacho, Ricardoc,d; Barroso, Helenaa,b; Bezerra, Victore; Taveira, Nunoa,b

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Seronegative HIV-1 infection has important implications for diagnosis and prevention. We describe a case of HIV-1 infection without seroconversion and fast progression to AIDS and death. Genetic and phylogenetic analysis indicated that the patient was infected with a CRF14_BG-like strain selectively transmitted by his seropositive sexual partner. The results suggest a massive infection with a highly aggressive CRF14_BG-like strain and/or the presence of an unidentified immunological deficiency that has prevented the formation of HIV-1-specific antibodies.

© 2009 Lippincott Williams & Wilkins, Inc.


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