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Impact of HIV infection on severity of imported malaria is restricted to patients with CD4 cell counts < 350 cells/μl

Mouala, Christiana,b; Guiguet, Margueritea,b; Houzé, Sandrinec; Damond, Florenced; Pialoux, Gillese; Viget, Nathalief; Costagliola, Dominiquea,b,g; Le Bras, Jacquesc; Matheron, Sophieh; on behalf of the FHDH-ANRS CO4 Clinical Epidemiology Group

doi: 10.1097/QAD.0b013e32832f4215
Clinical Science

Objectives: To study the relative impact of HIV-1 infection and associated immunodepression on the severity of Plasmodium falciparum malaria in adults returning from areas of endemic malaria.

Methods: We conducted a cross-sectional study, based on data from 104 HIV-infected patients from the French Hospital Database on HIV cohort (FHDH-ANRS CO4) and 161 HIV-negative patients from Bichat hospital, with a diagnosis of imported P. falciparum malaria between 2000 and 2003. The severity of falciparum malaria episode was graded with World Health Organization (WHO) criteria 2000 or on 2007 French recommendations.

Result: Depending on criteria used, 40% (WHO) and 28% (2007 French recommendations) of episodes of imported P. falciparum malaria in HIV-infected patients were classified as severe, compared with 21% (WHO) and 11% (2007 French recommendations) of episodes among HIV-negative patients. Among HIV-infected patients, the episodes were severe in between 22 (CD4 cell counts ≥350/μl) and 51% (CD4 cell counts <350/μl) of cases using WHO criteria, and between 12 (CD4 cell counts ≥350/μl) and 41% (CD4 cell counts <350/μl) of cases using 2007 French recommendations criteria. Relative to HIV-negative patients, after adjusting for confounding factors, HIV-infected patients with severe immunodepression (CD4 cell counts <350/μl) were at a significantly higher risk of severe malaria than HIV-negative patients (odds ratio 3.2–4.7, depending on the criteria) contrary to HIV-infected patients with CD4 cell counts more than 350/μl (odds ratio 0.7–0.9).

Conclusion: The association between HIV infection and severity of imported P. falciparum malaria is only observed for HIV-infected patients with severe immunodepression (CD4 cell counts <350/μl).

aINSERM U943, France

bUPMC Univ Paris 06, UMR S943, France

cHôpitaux de Paris (AP-HP), Groupe hospitalier Bichat Claude Bernard, Service de parasitologie, France

dAP-HP, Groupe hospitalier Bichat Claude Bernard, Service de virologie, France

eAP-HP, Groupe hospitalier Tenon, Service de maladies infectieuses et tropicales, France

fCentre Hospitalier de Tourcoing, Service universitaire des maladies infectieuses et du voyage, Tourcoing, France

gAP-HP, Groupe hospitalier Pitié-Salpêtrière, Service de maladies infectieuses et tropicales, France

hAP-HP, Groupe hospitalier Bichat Claude Bernard, Service de maladies infectieuses et tropicales, Paris, France.

* For the members of FHDH-ANRS CO4 Clinical Epidemiology Group, see acknowledgement.

Received 6 May, 2009

Revised 9 June, 2009

Accepted 9 June, 2009

Correspondence to Christian Mouala, INSERM U943, 56 Bd V Auriol, BP 335, 75625 Paris Cedex 13, France. Tel: +33 1 42 16 42 89; fax: +33 1 42 16 42 61; e-mail: cmouala@ccde.chups.jussieu.fr

© 2009 Lippincott Williams & Wilkins, Inc.