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Skip Navigation LinksHome > July 17, 2009 - Volume 23 - Issue 11 > Severe aseptic leucoencephalopathy as immune reconstitution...
AIDS:
doi: 10.1097/QAD.0b013e32832c4101
Research Letters

Severe aseptic leucoencephalopathy as immune reconstitution inflammatory syndrome in Caucasian and African patients

Ringelstein, Adriana; Oelschlaeger, Christiana,b; Saleh, Andreasa,b; Mathys, Christiana,b; Dziewas, Rainera,b; Niederstadt, Thomasa,b; Reichelt, Dorisa,b; Hasselblatt, Martina,b; Husstedt, Ingo Wa,b; Arendt, Gabrielea

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Abstract

Immune reconstitution inflammatory syndrome (IRIS) after HAART may become manifest in form of aseptic severe leucoencephalopathy. All HIV-1-positive patients in this case series had widespread laboratory tests and follow-up MRI in order to investigate the course and the underlying pathophysiology of IRIS-associated leucoencephalopathy. All patients were treated with corticosteroids, in spite of additional immunosuppression. Three patients were successfully treated with corticosteroids and survived up to now, one died. A neuropathological examination was performed showing massive aseptic intraparenchymal and perivascular invasion of cytotoxic CD8+ cells. It is assumed that IRIS-associated leucoencephalopathy is based on other preconditions in Africans and Caucasians.

© 2009 Lippincott Williams & Wilkins, Inc.

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