Human leukocyte antigen-G is an important suppressor of the immune response, and HIV can modulate its expression. Longitudinal monitoring of soluble human leukocyte antigen-G plasma levels in patients with primary HIV infection undergoing different rates of disease progression showed that levels were elevated in the early phases of infection and remained high throughout follow-up in rapid progressors who responded to antiretroviral therapy but were restored to normal levels in the chronic phase of infection in both untreated normal progressors and long-term nonprogressors.
aLaboratoire d'immunogénétique, Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Canada
bDépartement de Microbiologie et Immunologie de l'Université de Montréal, Canada
cResearch Institute of the McGill University Health Centre, Montreal, Québec, Canada.
Received 22 February, 2009
Revised 7 April, 2009
Accepted 17 April, 2009
Correspondence to Michel Roger, MD, PhD, Département de microbiologie, Hôpital Notre-Dame du CHUM, 1560 Sherbrooke Est, Montréal, Québec, Canada H2L 4M1. Tel: +1 514 890 8000 (25802); fax: +1 514 412 7512; e-mail: firstname.lastname@example.org