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Persistence of high levels of blood soluble human leukocyte antigen-G is associated with rapid progression of HIV infection

Lajoie, Juliea,b; Fontaine, Juliea,b; Tremblay, Cécileb; Routy, Jean-Pierrec; Poudrier, Johannea,b; Roger, Michela,b

doi: 10.1097/QAD.0b013e32832d0825
Research Letters

Human leukocyte antigen-G is an important suppressor of the immune response, and HIV can modulate its expression. Longitudinal monitoring of soluble human leukocyte antigen-G plasma levels in patients with primary HIV infection undergoing different rates of disease progression showed that levels were elevated in the early phases of infection and remained high throughout follow-up in rapid progressors who responded to antiretroviral therapy but were restored to normal levels in the chronic phase of infection in both untreated normal progressors and long-term nonprogressors.

aLaboratoire d'immunogénétique, Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Canada

bDépartement de Microbiologie et Immunologie de l'Université de Montréal, Canada

cResearch Institute of the McGill University Health Centre, Montreal, Québec, Canada.

Received 22 February, 2009

Revised 7 April, 2009

Accepted 17 April, 2009

Correspondence to Michel Roger, MD, PhD, Département de microbiologie, Hôpital Notre-Dame du CHUM, 1560 Sherbrooke Est, Montréal, Québec, Canada H2L 4M1. Tel: +1 514 890 8000 (25802); fax: +1 514 412 7512; e-mail: michel.roger.chum@ssss.gouv.qc.ca

© 2009 Lippincott Williams & Wilkins, Inc.