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Transmission probabilities of HIV and herpes simplex virus type 2, effect of male circumcision and interaction: a longitudinal study in a township of South Africa

Mahiane, Séverin-Guya; Legeai, Camilleb; Taljaard, Dirkc; Latouche, Auréliend; Puren, Adriane; Peillon, Aurélief; Bretagnolle, Jeang; Lissouba, Pascalef; Nguéma, Eugène-Patrice Ndonga; Gassiat, Elisabethg; Auvert, Bertranb,d,f

doi: 10.1097/QAD.0b013e32831c5497
Epidemiology and Social

Objectives: A synergy between HIV and herpes simplex virus type 2 (HSV-2) infections has been reported in observational studies. The objectives of this study were to estimate the per-sex-act female-to-male transmission probabilities (FtoMTPs) of HIV and HSV-2, the effect of each infection on the FtoMTP of the other and the effect of male circumcision on these FtoMTPs.

Design: We used longitudinal data collected during the male circumcision trial conducted in Orange Farm (South Africa).

Methods: Results were obtained by specific mathematical modeling of HIV and HSV-2 statuses of the men as functions of their sexual behavior and male circumcision status. The model took into account an estimation of the HIV and HSV-2 statuses of each of their female partners. Confidence intervals (CI) were estimated using a bootstrap re-sampling method.

Results: The HIV and HSV-2 FtoMTPs, during an unprotected sexual contact for an uncircumcised male in the absence of the other virus in both partners, were 0.0047 (95% CI: 0.0014–0.017) and 0.0067 (95% CI: 0.0028–0.014), respectively. HSV-2 in either partner increased HIV FtoMTP with a relative risk (RR) of 3.0 (95% CI: 1.01–7.3). Conversely, HIV in either partner increased HSV-2 FtoMTP (RR = 2.5; 95% CI: 1.1–6.3). Male circumcision significantly decreased these probabilities with RRs of 0.24 (95% CI: 0.11–0.44) and 0.59 (95% CI: 0.36–0.91), respectively.

Conclusion: This study gave the first estimates of HSV-2 per-sex-act FtoMTPs in Africa. It demonstrated a synergy between HIV and HSV-2 infections and a protective effect of male circumcision on HSV-2 acquisition by males.

aEcole Nationale Supérieure Polytechnique de Yaoundé, Cameroon, South Africa

bHôpital Ambroise-Paré, APHP, Boulogne, France

cProgressus, Johannesburg, South Africa

dUniversity of Versailles, Versailles, France

eNational Institute for Communicable Diseases, Johannesburg, South Africa

fINSERM, Villejuif, France

gLaboratoire de Mathématiques UMR, Paris-11 University, France.

Received 15 April, 2008

Revised 29 September, 2008

Accepted 30 September, 2008

Correspondence to Prof Bertran Auvert, INSERM U687, 16 avenue, Paul Vaillant-Couturier, 94804 Villejuif Cedex, France. E-mail: Bertran.auvert@uvsq.fr

© 2009 Lippincott Williams & Wilkins, Inc.