The diversity of HIV-1 and human genetics complicates our ability to determine the impact of treatment during primary HIV-1 infection on disease outcome. Here, we show, in a small group infected with virtually identical HIV-1 strains and treated during primary HIV-1 infection, that patients expressing protective human leucocyte antigen alleles had lower viral loads following treatment discontinuation. These data suggest that genetic factors play an important role in the outcome of HIV-1 infection despite early therapy.
aPartners AIDS Research Center, Division of Infectious Diseases, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA
bHIV Clinic Dres. Jessen, Jessen, Stein, Berlin, Germany
cRobert Koch Institute, Berlin, Germany
dHIV Clinic Baumgarten, Carganico, Dupke, Berlin, Germany
eUniversity Medical Center Hamburg-Eppendorf, Infectious Diseases Unit, Germany
fHeinrich Pette Institute for Experimental Virology and Immunology, Hamburg, Germany
gHoward Hughes Medical Institute, Chevy Chase, Maryland, USA.
* These authors contributed equally.
Correspondence to Todd M. Allen, PhD, MGH-East, CNY 6625, 149 13th Street, Charlestown, MA 02129, USA. Tel: +1 617 726 7846; fax: +1 617 724 8586; e-mail: firstname.lastname@example.org