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A common human leucocyte antigen-DP genotype is associated with resistance to HIV-1 infection in Kenyan sex workers

Hardie, Rae-Annea; Knight, Erinb; Bruneau, Brigitteb; Semeniuk, Christinab; Gill, Kulvindera; Nagelkerke, Nicoc; Kimani, Joshuad; Wachihi, Charlese; Ngugi, Elizabethe; Luo, Maa; Plummer, Francis Aa,b,d

doi: 10.1097/QAD.0b013e328311d1a0
Research Letters

Human leucocyte antigen-DP presents peptides to CD4+ T cells and plays an important role in parasitic infections and autoimmune diseases, yet its influence on HIV-1 susceptibility has not been well studied. Here, we report several human leucocyte antigen-DP genotypes associated with HIV-1 susceptibility in Kenyan sex workers. Among these, one common genotype stands out. DPA1*010301 (frequency = 60.4%) was associated with HIV-1 resistance (P = 0.033, odds ratio = 1.585, 95% confidence interval = 1.036–2.425) and slower seroconversion (P = 0.001, log rank = 0.595, 95% confidence interval = 0.433–0.817). The discovery of common human leucocyte antigen-DP genotypes contributing to HIV-1 immunity may help overcome difficulties encountered with highly polymorphic human leucocyte antigens.

aDepartment of Medical Microbiology, University of Manitoba, Canada

bPublic Health Agency of Canada, Winnipeg, Manitoba, Canada

cDepartment of Community Medicine, UAE University, Al Ain, United Arab Emirates, Kenya

dDepartment of Medical Microbiology, Kenya

eDepartment of Community Health, University of Nairobi, Nairobi, Kenya.

Correspondence to Dr Ma Luo, PhD, Medical Microbiology, Room #507, Basic Medical Sciences Building, 730 William Avenue, Winnipeg, MB R3E 0W3, Canada. Tel: +1 204 789 5072; fax: +1 204 789 2018; e-mail: mluo@cc.umanitoba.ca

© 2008 Lippincott Williams & Wilkins, Inc.