Human leucocyte antigen-DP presents peptides to CD4+ T cells and plays an important role in parasitic infections and autoimmune diseases, yet its influence on HIV-1 susceptibility has not been well studied. Here, we report several human leucocyte antigen-DP genotypes associated with HIV-1 susceptibility in Kenyan sex workers. Among these, one common genotype stands out. DPA1*010301 (frequency = 60.4%) was associated with HIV-1 resistance (P = 0.033, odds ratio = 1.585, 95% confidence interval = 1.036–2.425) and slower seroconversion (P = 0.001, log rank = 0.595, 95% confidence interval = 0.433–0.817). The discovery of common human leucocyte antigen-DP genotypes contributing to HIV-1 immunity may help overcome difficulties encountered with highly polymorphic human leucocyte antigens.
aDepartment of Medical Microbiology, University of Manitoba, Canada
bPublic Health Agency of Canada, Winnipeg, Manitoba, Canada
cDepartment of Community Medicine, UAE University, Al Ain, United Arab Emirates, Kenya
dDepartment of Medical Microbiology, Kenya
eDepartment of Community Health, University of Nairobi, Nairobi, Kenya.
Correspondence to Dr Ma Luo, PhD, Medical Microbiology, Room #507, Basic Medical Sciences Building, 730 William Avenue, Winnipeg, MB R3E 0W3, Canada. Tel: +1 204 789 5072; fax: +1 204 789 2018; e-mail: firstname.lastname@example.org