Skip Navigation LinksHome > September 12, 2008 - Volume 22 - Issue 14 > Mucosal Neisseria gonorrhoeae coinfection during HIV acquisi...
doi: 10.1097/QAD.0b013e32830baf5e
Basic Science

Mucosal Neisseria gonorrhoeae coinfection during HIV acquisition is associated with enhanced systemic HIV-specific CD8 T-cell responses

Sheung, Anthonya; Rebbapragada, Anua; Shin, Lucy YYa; Dobson-Belaire, Wendyb; Kimani, Joshuac; Ngugi, Elizabethd; MacDonald, Kelly Sa,e; Bwayo, Job Jc,†; Moses, Stephenf; Gray-Owen, Scottb; Kaul, Ruperta,c,g; The Kibera HIV Study Group

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Background: The host immune response against mucosally acquired pathogens may be influenced by the mucosal immune milieu during acquisition. As Neisseria gonorrhoeae can impair dendritic cell and T-cell immune function, we hypothesized that coinfection during HIV acquisition would impair subsequent systemic T-cell responses.

Methods: Monthly screening for sexually transmitted infections was performed in high risk, HIV seronegative Kenyan female sex workers as part of an HIV prevention trial. Early HIV-specific CD8 T-cell responses and subsequent HIV viral load set point were assayed in participants acquiring HIV, and were correlated with the presence of prior genital infections during HIV acquisition.

Results: Thirty-five participants acquired HIV during follow-up, and 16 out of 35 (46%) had a classical sexually transmitted infection at the time of acquisition. N. gonorrhoeae coinfection was present during HIV acquisition in 6 out of 35 (17%), and was associated with an increased breadth and magnitude of systemic HIV-specific CD8 T-cell responses, using both interferon-gammaγ and MIP-1 beta as an output. No other genital infections were associated with differences in HIV-specific CD8 T-cell response, and neither N. gonorrhoeae nor other genital infections were associated with differences in HIV plasma viral load at set point.

Conclusion: Unexpectedly, genital N. gonorrhoeae infection during heterosexual HIV acquisition was associated with substantially enhanced HIV-specific CD8 T-cell responses, although not with differences in HIV viral load set point. This may have implications for the development of mucosal HIV vaccines and adjuvants.

© 2008 Lippincott Williams & Wilkins, Inc.


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