A brief history of HIV vaccine research: stepping back to the drawing board?Miedema, FrankAIDS: 12 September 2008 - Volume 22 - Issue 14 - p 1699–1703 doi: 10.1097/QAD.0b013e3283021a61 Opinion Abstract Author Information In September 2007, it was announced that the most promising HIV vaccine trial had to be stopped because it had failed to show the protection that was hoped for. Here, the history of HIV vaccine development from the discovery of HIV-1 in 1983 until 2008, the underlying ideas on protective immunity to HIV and potential avenues for vaccine research are discussed. University Medical Center Utrecht, Utrecht, The Netherlands. Received 14 December, 2007 Accepted 25 March, 2008 Correspondence to Frank Miedema, University Medical Center Utrecht, Lundlaan 6, 3584EA Utrecht, The Netherlands. E-mail: email@example.com © 2008 Lippincott Williams & Wilkins, Inc.