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The IL-6 system in HIV-1-infection and in HAART-related fat redistribution syndromes

Saumoy, Mariaa; López-Dupla, Miguela; Veloso, Sergia; Alonso-Villaverde, Carlosb; Domingo, Perec; Broch, Montserrata,d; Miranda, Mercea,e; Coll, Blaib; Saurí, Amadeua; Vendrell, Joana,e; Richart, Cristóbala,d; Vidal, Francesca

doi: 10.1097/QAD.0b013e3282f4dde7
Research Letters

We determined the IL-6 −174 G>C single nucleotide polymorphism, IL-6 mRNA expression in subcutaneous adipose tissue (SAT) and IL-6 plasma levels in HIV-1-infected patients with and without lipodystrophy and uninfected controls. HIV-1-infected patients had a greater prevalence of the IL-6 −174 C/C genotype and the C allele, higher SAT IL-6 mRNA expression and plasma IL-6 levels than controls. The IL-6 −174 G>C genotype distribution and allele frequencies, SAT IL-6 mRNA expression and IL-6 plasma levels were non-significantly different between HIV-1-infected patients with and without lipodystrophy.

aHospital Universitari de Tarragona Joan XXIII, Universitat Rovira i Virgili, Tarragona, Spain

bHospital Universitari de Sant Joan, Reus, Spain

cHospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain

dCIBER Fisiopatologia de la Obesidad y Nutrición (CB 06/03), Instituto de Salud Carlos III, Madrid, Spain

eCIBER Diabetes (CB 07/08/0012), Instituto de Salud Carlos III, Madrid, Spain.

Received 29 June, 2007

Revised 13 November, 2007

Accepted 27 November, 2007

© 2008 Lippincott Williams & Wilkins, Inc.