We determined the IL-6 −174 G>C single nucleotide polymorphism, IL-6 mRNA expression in subcutaneous adipose tissue (SAT) and IL-6 plasma levels in HIV-1-infected patients with and without lipodystrophy and uninfected controls. HIV-1-infected patients had a greater prevalence of the IL-6 −174 C/C genotype and the C allele, higher SAT IL-6 mRNA expression and plasma IL-6 levels than controls. The IL-6 −174 G>C genotype distribution and allele frequencies, SAT IL-6 mRNA expression and IL-6 plasma levels were non-significantly different between HIV-1-infected patients with and without lipodystrophy.
aHospital Universitari de Tarragona Joan XXIII, Universitat Rovira i Virgili, Tarragona, Spain
bHospital Universitari de Sant Joan, Reus, Spain
cHospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain
dCIBER Fisiopatologia de la Obesidad y Nutrición (CB 06/03), Instituto de Salud Carlos III, Madrid, Spain
eCIBER Diabetes (CB 07/08/0012), Instituto de Salud Carlos III, Madrid, Spain.
Received 29 June, 2007
Revised 13 November, 2007
Accepted 27 November, 2007