Skip Navigation LinksHome > March 30, 2008 - Volume 22 - Issue 6 > Specific stimulation of HIV-1 replication in human placental...
doi: 10.1097/QAD.0b013e3282f560ee
Research Letters

Specific stimulation of HIV-1 replication in human placental trophoblasts by an antigen of Plasmodium falciparum

Ayouba, Ahidjoa; Badaut, Cyrilb; Kfutwah, Anfumbomc; Cannou, Claudea; Juillerat, Alexandreb; Gangnard, Stéphaneb; Behr, Charlotted; Mercereau-Puijalon, Odiled; Bentley, Graham Ab; Barré-Sinoussi, Françoisea; Menu, Elisabetha

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Epidemiological data point to an increased risk of HIV-1 mother-to-child transmission in pregnant women with malaria, by unknown mechanisms. We show here that surface binding of a recombinant Plasmodium falciparum adhesin to chondroitin sulphate A proteoglycans increases HIV-1 replication in the human placental cell line BeWo, probably by a P. falciparum adhesin-induced long-terminal repeat-driven TNF-α stimulation. This suggests that placental malaria could increase the risk of HIV-1 transmission in utero.

© 2008 Lippincott Williams & Wilkins, Inc.


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