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The role of protective HCP5 and HLA-C associated polymorphisms in the control of HIV-1 replication in a subset of elite suppressors

Han, Yefei; Lai, Jun; Barditch-Crovo, Patricia; Gallant, Joel E; Williams, Thomas M; Siliciano, Robert F; Blankson, Joel N

doi: 10.1097/QAD.0b013e3282f470e4
Research Letters

Elite suppressors (ES) are untreated HIV-1-infected patients who maintain undetectable viral loads. A recent whole-genome analysis identified two independent polymorphisms associated with low viral loads in untreated HIV-1 infection. We screened 16 ES; none were positive for the protective HLA complex 5 gene polymorphism, and only four were positive for the protective polymorphism associated with the HLA-C gene. These results suggest that some ES control viremia by mechanisms independent of the newly-identified genetic factors.

Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Received 24 October, 2007

Revised 31 October, 2007

Accepted 13 November, 2007

© 2008 Lippincott Williams & Wilkins, Inc.