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HLA-DRB1*01 associated with cutaneous hypersensitivity induced by nevirapine and efavirenz

Vitezica, Zulma Ga,b; Milpied, Brigittec; Lonjou, Christinea,b; Borot, Nicolasa,b; Ledger, Terence Nield; Lefebvre, Annee; Hovnanian, Alaina,b

doi: 10.1097/QAD.0b013e3282f37812
Research Letters

HLA typing, demographic and immunological risk factors for nevirapine and efavirenz reactions were studied in a French cohort of HIV patients. Cases with isolated rash were significantly associated with HLA-DRB1*01 allele. No liver toxicity was observed and no association was detected with the percentage of CD4 T-cells. This study suggests that HLA-DRB1*01 allele plays an important role in susceptibility to cutaneous reactions associated with nevirapine and efavirenz in HIV patients.

aINSERM, U563, Centre de Physiopathologie de Toulouse Purpan, Toulouse, France

bUniversité Toulouse III Paul-Sabatier, UMRs563, Toulouse, France

cCHU Bordeaux, Service de Dermatologie, Hôpital Saint André, Bordeaux France

dLIPM, CNRS INRA UMR 2594, Castanet Tolosan, France

eCHU Nantes, Service de Dermatologie, Nantes France.

Received 20 September, 2007

Accepted 18 October, 2007

© 2008 Lippincott Williams & Wilkins, Inc.