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Prevalence and impact of HIV-1 protease mutation L76V on lopinavir resistance

de Mendoza, Carmen; Garrido, Carolina; Corral, Angélica; Zahonero, Natalia; Soriano, Vincent

doi: 10.1097/QAD.0b013e3282f4244f
Research Letters

Besides I47A, mutation L76V at the HIV protease gene has recently been proposed to cause lopinavir resistance. This change was present in 37 (2.7%) out of 1376 patients failing protease inhibitor containing regimens. Although 26 (70%) were on lopinavir, most had previously failed other protease inhibitors and carried multiple protease inhibitor resistance mutations. Therefore, L76V does not appear to be a primary lopinavir resistance change when the drug is used in combination therapy.

Department of Infectious Diseases, Hospital Carlos III, Madrid, Spain.

Received 26 June, 2007

Revised 24 October, 2007

Accepted 2 November, 2007

© 2008 Lippincott Williams & Wilkins, Inc.