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Undetectable hepatitis C virus RNA at week 4 as predictor of sustained virological response in HIV patients with chronic hepatitis C

Martin-Carbonero, Luza; Nuñez, Marinaa; Mariño, Anab; Alcocer, Federicoc; Bonet, Llucíad; García-Samaniego, Javiera; López-Serrano, Pilare; Cordero, Miguelf; Portu, Josebag; Soriano, Vincenta

AIDS:
doi: 10.1097/QAD.0b013e3282f1da99
Basic Science
Abstract

Background: Low baseline serum hepatitis C virus (HCV)-RNA and clearance of viraemia at week 4 with pegylated interferon (pegIFN) plus ribavirin therapy predict sustained virological response (SVR) and enable a shorter duration of therapy in patients with chronic hepatitis C. It is unclear whether this applies to HIV/HCV-co-infected patients.

Patients and methods: In the Peginterferon Ribavirin ESpaña COinfection (PRESCO) trial, 389 co-infected patients received pegIFN-α2a 180 μg/week plus ribavirin 1000–1200 mg/day. Patients with HCV-2/3 were treated for 6 or 12 months, whereas patients with HCV-1/4 were treated for 12 or 18 months. For each genotype, baseline HCV-RNA and rapid virological response (RVR), defined as under 50 IU/ml HCV-RNA at week 4, were evaluated as predictors of SVR in an ‘on-treatment’ analysis.

Results: Overall, SVR was achieved by 193 patients (49.6%), 68/191 (35.6%) with genotype 1, 110/152 (72.4%) with genotypes 2/3 and 15/46 (32.6%) with genotype 4. RVR was the best predictor of SVR regardless of HCV genotype. Only for HCV-1 patients, baseline HCV-RNA less than 500 000 IU/ml was also associated with SVR. In HCV-3 patients RVR had a positive predictive value (PPV) for SVR of 90%, with treatment for 24 or 48 weeks. The PPV of SVR for patients with RVR was 69% for HCV-1 and 83% for HCV-4.

Conclusion: Undetectable HCV-RNA at week 4 is the best predictor of curing chronic hepatitis C in HCV/HIV-co-infected patients. In HCV-1 patients, baseline HCV-RNA also predicts response. HIV patients with HCV-3 and RVR may permit shortening therapy duration to only 24 weeks of pegIFN plus 1000–1200 mg ribavirin.

Author Information

From the aHospital Carlos III, CIBEREHD, Madrid, Spain

bHospital Arquitecto Marcide, Ferrol, Spain

cHospital Clínico, Valencia, Spain

dHospital Son Dureta, Palma de Mallorca, Spain

eFundación Hospital de Alcorcón, Madrid, Spain

fHospital Universitario, Salamanca, Spain

gHospital Txagorritxu, Vitoria, Spain.

Received 4 April, 2007

Revised 29 May, 2007

Accepted 7 June, 2007

Correspondence to Vincent Soriano, Department of Infectious Diseases, Hospital Carlos III, Calle Sinesio Delgado 10, Madrid 28029, Spain. Tel: +34 91 4532500; fax: +34 91 7336614; e-mail: vsoriano@dragonet.es

© 2008 Lippincott Williams & Wilkins, Inc.