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Prospective HLA-B*5701 screening and abacavir hypersensitivity: a single centre experience

Waters, Laura J; Mandalia, Sundhiya; Gazzard, Brian; Nelson, Mark

doi: 10.1097/QAD.0b013e328273bc07
Research Letters

Suspected hypersensitivity is the main reason for the early discontinuation of abacavir. After the observation that the risk of hypersensitivity correlated with ethnicity, the presence of the HLA allele B*5701 was found to be the strongest retrospective predictor of hypersensitivity. Two prospective cohorts have since demonstrated a significant reduction in abacavir hypersensitivity rates with the use of prospective human leukocyte antigen screening. We describe our experience of prospective HLA-B*5701 testing and the impact on rates of abacavir hypersensitivity.

Department of GU/HIV Medicine, St Stephen's Centre, Chelsea and Westminster Hospital, London, UK.

Received 9 May, 2007

Accepted 11 May, 2007

© 2007 Lippincott Williams & Wilkins, Inc.