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Skip Navigation LinksHome > November 30, 2007 - Volume 21 - Issue 18 > Prospective HLA-B*5701 screening and abacavir hypersensitivi...
AIDS:
doi: 10.1097/QAD.0b013e328273bc07
Research Letters

Prospective HLA-B*5701 screening and abacavir hypersensitivity: a single centre experience

Waters, Laura J; Mandalia, Sundhiya; Gazzard, Brian; Nelson, Mark

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Abstract

Suspected hypersensitivity is the main reason for the early discontinuation of abacavir. After the observation that the risk of hypersensitivity correlated with ethnicity, the presence of the HLA allele B*5701 was found to be the strongest retrospective predictor of hypersensitivity. Two prospective cohorts have since demonstrated a significant reduction in abacavir hypersensitivity rates with the use of prospective human leukocyte antigen screening. We describe our experience of prospective HLA-B*5701 testing and the impact on rates of abacavir hypersensitivity.

© 2007 Lippincott Williams & Wilkins, Inc.

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