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Increased incidence of mucosal candidiasis after HAART initiation: a benign form of immune reconstitution disease?

Nacher, Mathieua,b; Vantilcke, Vincentc; Huber, Florenced; Mahamat, Abae; El Guedj, Myriamc; Randrianjohany, Andryf; Clyti, Emmanuelb,d; Aznar, Christineb,g; Carme, Bernardb,g; Couppié, Pierreb,d

doi: 10.1097/QAD.0b013e3282f02a3a
Research Letters

Immune reconstitution after HAART initiation is often complicated by adverse clinical manifestations caused either by the unmasking of preexisting untreated opportunistic infections or the clinical deterioration of a known and treated opportunistic infection. The present study was conducted to determine whether the initiation of HAART was followed by an increase in the incidence of mucosal candidiases, a possible manifestation of immune reconstitution disease of the unmasking type.

aCOREVIH Cayenne General Hospital, Cayenne, French Guiana

bEquipe EA 3593, Université Antilles Guyane, Campus Saint Denis, Cayenne, French Guiana

cDay Hospital, Cayenne General Hospital, Cayenne, French Guiana

dDepartment of Dermatology, Cayenne General Hospital, Cayenne, French Guiana

eDepartment of Infectious Diseases, Cayenne General Hospital, Cayenne, French Guiana

fDepartment of Medicine, Saint Laurent du Maroni, French Guiana

gDepartment of Parasitology-Mycology, Cayenne General Hospital, Cayenne, French Guiana.

Received 22 June, 2007

Revised 12 July, 2007

Accepted 18 July, 2007

© 2007 Lippincott Williams & Wilkins, Inc.