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Do CD8+CD25+ cells predict immune reconstitution syndrome in HIV-positive patients who begin HAART?

Cianchetta-Sívori, Malenaa; Raso, Sandraa; Fernández-Guerrero, Manuelb; Górgolas, Miguelb; García, Rosaa

doi: 10.1097/QAD.0b013e3282f125da
Research Letters

Although undesirable, immune reconstitution syndrome (IRS) indicates a favourable effect of HAART and it should be differentiated from an opportunistic infection because of their distinct implications and management. Our group analysed different immunological parameters with the aim of identifying IRS predictors in patients who begin HAART. We found that CD8+CD25+ cell pretreatment values in patients who developed IRS were four times higher than in those patients who did not develop IRS.

aDepartment of Immunology, Fundación Jimenez Díaz-Capio, Madrid, Spain

bDepartment of Infectious Diseases, Fundación Jimenez Díaz-Capio, Madrid, Spain.

Received 3 August, 2007

Revised 9 August, 2007

Accepted 13 August, 2007

© 2007 Lippincott Williams & Wilkins, Inc.