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Skip Navigation LinksHome > October 1, 2007 - Volume 21 - Issue 15 > The intestinal mucosa as a reservoir of HIV-1 infection afte...
AIDS:
doi: 10.1097/QAD.0b013e3282efb74b
Research Letters

The intestinal mucosa as a reservoir of HIV-1 infection after successful HAART

Belmonte, Lilianaa; Olmos, Martinc; Fanin, Anac; Parodi, Ceciliaa; Baré, Patriciaa; Concetti, Hugod; Pérez, Héctorb; de Bracco, Maria Marta Ea; Cahn, Pedrob

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Abstract

The presence of HIV-1 RNA in distal duodenal mucosa was evaluated in 44 HIV-1-positive patients. HIV-1 RNA was detected in gut tissue in antiretroviral-naive patients with high plasma viral loads, as well as in patients on HAART with plasma viral loads below the limit of detection and in patients on HAART with virological failure. The intestinal mucosa seems to serve as a reservoir poorly influenced by levels of plasma viral load or HAART.

© 2007 Lippincott Williams & Wilkins, Inc.

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