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Prevalence and factors associated with dry skin in HIV infection: the FRAM study

Lee, Daniela; Benson, Constance Aa; Lewis, Cora Eb; Grunfeld, Carlc,d; Scherzer, Rebeccad

doi: 10.1097/QAD.0b013e3282eea51a
Clinical Science

Objective: Complaints of dry skin in HIV-infected individuals were reported after the advent of HAART. The objective of the study was to evaluate the prevalence of dry skin and associated factors in HIV-infected and control subjects.

Design: Cross-sectional.

Methods: A total of 1026 HIV-infected subjects and 274 controls [from the Coronary Artery Risk Development in Young Adults (CARDIA) study, a population-based study of cardiovascular risk assessment] in the Study of Fat Redistribution and Metabolic Change in HIV infection (FRAM) had skin assessed by self-report and examination. Multivariable logistic regression identified factors associated with dry skin.

Results: Self-reported dry skin was more prevalent in HIV-infected subjects than controls. In multivariable analysis, HIV infection was associated with self-reported dry skin. In HIV-infected men, current indinavir use, CD4 cell count less than 200 cells/μl and recent opportunistic infections were associated with dry skin. Indinavir use had an elevated risk in men with CD4 cell counts of 200 cells/μl or greater but not with CD4 cell counts less than 200 cells/μl. In HIV-infected women, a CD4 cell count less than 200 cells/μl was associated with dry skin; indinavir use did not reach statistical significance but, as in men, indinavir use had an elevated risk in those with higher CD4 cell counts than in those with CD4 cell counts less than 200 cells/μl.

Conclusion: Dry skin is more common in HIV-infected individuals than controls. In HIV-infected individuals, low CD4 cell counts and indinavir use in those with higher CD4 cell counts are associated with dry skin.

From the aDepartment of Medicine, University of California, San Diego, California, USA

bDivision of Preventive Medicine, University of Alabama, Birmingham, Alabama, USA

cDepartment of Medicine, University of California, San Francisco, California, USA

dMetabolism Section, San Francisco Veterans Affairs Medical Center, San Francisco, California, USA.

Received 4 May, 2007

Revised 1 June, 2007

Accepted 18 July, 2007

Correspondence to Carl Grunfeld, MD, PhD, Office of the Principal Investigator, The FRAM Study, University of California, San Francisco, Veterans Affairs Medical Center, Metabolism Section 111F, 4150 Clement Street, San Francisco, CA 94121, USA. Tel: +1 415 750 2005; fax: +1 415 750 6927; e-mail: carl.grunfeld@ucsf.edu

© 2007 Lippincott Williams & Wilkins, Inc.