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Effect of tenofovir on renal glomerular and tubular function

Fux, Christoph Aa; Christen, Annaa; Zgraggen, Susannea; Mohaupt, Markus Gb; Furrer, Hansjakoba

doi: 10.1097/QAD.0b013e328216f15b
Research Letters

To evaluate tenofovir-related nephropathy, we quantified calculated glomerular filtration rates (GFR) and renal tubular function in 46 tenofovir-treated patients and 25 without tenofovir. We also analysed patients who stopped tenofovir for drug-related nephrotoxicity at our clinic. Tenofovir use combined with non-nucleoside reverse transcriptase inhibitors, but not with protease inhibitors, resulted in a significant increase in calculated GFR. Tenofovir use was associated with significantly lower phosphatemia and a marginally increased fractional excretion of uric acid, but no other signs of tubulopathy.

aDivision of Infectious Diseases, University Hospital, Berne, Switzerland

bDepartment of Nephrology and Hypertension, University Hospital, Berne, Switzerland.

Received 27 September, 2006

Revised 6 March, 2007

Accepted 16 March, 2007

© 2007 Lippincott Williams & Wilkins, Inc.