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Antiviral therapy for hepatitis C virus recurrence after liver transplantation in HIV-infected patients: outcome in the Bonn cohort

Wojcik, Kamilaa; Vogel, Martinb; Voigt, Estherb; Speidel, Nicolac; Kalff, Jörg Cc; Goldmann, Georgd; Oldenburg, Johannesd; Sauerbruch, Tilmanb; Rockstroh, Jürgen Kurtb; Spengler, Ulrichb

doi: 10.1097/QAD.0b013e3280d5a79a
Research Letters

Recurrent hepatitis C is a major cause of mortality in HIV/hepatitis C virus (HCV)-co-infected patients after orthotopic liver transplantation. We report sustained viral clearance in all four transplanted HIV/HCV-positive patients treated with pegylated interferon/ribavirin. Early therapy after HCV recurrence, tailoring treatment duration to the individual decline in HCV-RNA and the management of side effects are key factors for improved efficacy. At experienced centres interferon treatment is a valuable option for recurrent hepatitis C in HIV-positive patients.

aDepartment of Infectious Diseases and Hepatology, Medical University of Lodz, 91-347 Lodz, Poland

bDepartments of Internal Medicine I, Germany

cSurgery, Germany

dInstitute of Experimental Hematology and Transfusion Medicine, University of Bonn, D-53105 Bonn, Germany.

Received 17 November, 2006

Accepted 28 November, 2006

© 2007 Lippincott Williams & Wilkins, Inc.