AIDS

Skip Navigation LinksHome > April 23, 2007 - Volume 21 - Issue 7 > Primary genotypic resistance of HIV-1 to the maturation inhi...
AIDS:
doi: 10.1097/QAD.0b013e3280b079d9
Research Letters

Primary genotypic resistance of HIV-1 to the maturation inhibitor PA-457 in protease inhibitor-experienced patients

Malet, Isabellea; Wirden, Marca; Derache, Annea; Simon, Anneb; Katlama, Christinec,d; Calvez, Vincenta; Marcelin, Anne-Genevièvea

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Abstract

Sequences from 82 protease inhibitors (PI)-experienced patients were analysed for the presence of previously described in-vitro resistance mutations to PA-457 located in the C-terminal capside (H226Y, L231F, L231M) and in the N-terminal SP1 (A1V, A3T, A3V) within the CA-SP1 boundary domain. Overall, the CA-SP1 cleavage site was highly conserved in PI pre-treated patients and only one patient showed an L231M mutation. The impact of this mutation should be further addressed in vivo.

© 2007 Lippincott Williams & Wilkins, Inc.

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