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Elevated plasma levels of high mobility group box protein 1 in patients with HIV-1 infection

Nowak, Piotra; Barqasho, Babiloniaa; Sönnerborg, Andersa,b

doi: 10.1097/QAD.0b013e3280b079b6
Research Letters

High mobility group box protein 1 (HMGB1) is a potent proinflammatory mediator. It has a dichotomic effect on HIV-1 replication in vitro but its role in vivo is unknown. Here we report the novel finding that plasma HMGB1 levels are elevated in HIV-1-infected patients, with the highest concentrations in patients with clinical complications. HMGB1 is likely to contribute to immunoactivation in HIV-1 infection in vivo.

aDivisions of Clinical Virology, Sweden

bInfectious Diseases, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

Received 20 November, 2006

Revised 11 December, 2006

Accepted 19 December, 2006

© 2007 Lippincott Williams & Wilkins, Inc.