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Tuberculous meningitis in HIV-infected patients: drug susceptibility and clinical outcome

Cecchini, Diegoa; Ambrosioni, Juana; Brezzo, Clarisaa; Corti, Marceloa; Rybko, Anab; Perez, Marcelab; Poggi, Susanab; Ambroggi, Martab

doi: 10.1097/QAD.0b013e328012b84d
Research Letters

The objective of this study was to identify prognostic factors of death in patients with tuberculous meningitis (TM) and show the impact of infection by multidrug-resistant strains on the outcome of this disease. We retrospectively analysed clinical charts of HIV-infected patients with culture-confirmed TM attending our institution during 1996–2004. The following variables were associated with death during hospitalization: neurological signs at admission, a CD4 T-cell count less than 50 cells/μl and infection by multidrug-resistant strains.

Author Information

aInfectious Diseases Division, Argentina

b‘Abel J. Cetrángolo’ Laboratory of Mycobacterias, Infectious Diseases ‘Francisco Javier Muñiz’ Hospital, Buenos Aires, Argentina.

Received 29 June, 2006

Revised 6 October, 2006

Accepted 30 October, 2006

© 2007 Lippincott Williams & Wilkins, Inc.