The objective of this study was to identify prognostic factors of death in patients with tuberculous meningitis (TM) and show the impact of infection by multidrug-resistant strains on the outcome of this disease. We retrospectively analysed clinical charts of HIV-infected patients with culture-confirmed TM attending our institution during 1996–2004. The following variables were associated with death during hospitalization: neurological signs at admission, a CD4 T-cell count less than 50 cells/μl and infection by multidrug-resistant strains.
aInfectious Diseases Division, Argentina
b‘Abel J. Cetrángolo’ Laboratory of Mycobacterias, Infectious Diseases ‘Francisco Javier Muñiz’ Hospital, Buenos Aires, Argentina.
Received 29 June, 2006
Revised 6 October, 2006
Accepted 30 October, 2006