AIDS

Skip Navigation LinksHome > January 30, 2007 - Volume 21 - Issue 3 > Three-year follow-up of protease inhibitor-based regimen sim...
AIDS:
doi: 10.1097/QAD.0b013e3280121ab1
Research Letters

Three-year follow-up of protease inhibitor-based regimen simplification in HIV-infected patients

Martínez, Estebana; Arnaiz, Juan Aa; Podzamczer, Danielb; Dalmau, Davidc; Ribera, Esteband; Domingo, Peree; Knobel, Hernandof; Leyes, Mariag; Pedrol, Enrich; Force, Luísi; de Lazzari, Elisaa; Gatell, José Ma

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Abstract

Patients with sustained virological suppression on protease inhibitor (PI)-based therapy were randomly assigned to switch the PI to nevirapine (n = 155), efavirenz (n = 156), or abacavir (n = 149) and were followed for at least 3 years regardless of the discontinuation of assigned therapy. There was a higher probability of maintaining virological suppression after 3 years of follow-up with nevirapine or efavirenz than with abacavir. In contrast, abacavir showed a lower incidence of adverse effects leading to drug discontinuation.

© 2007 Lippincott Williams & Wilkins, Inc.

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