Large intra-individual variability in plasma levels may limit the interest of therapeutic drug monitoring based on a single determination. Indinavir concentrations were determined both in plasma and hair samples, and correlated with concomitant plasma HIV-RNA in 43 HIV-infected patients. In multivariate analysis, significant association was found between HIV-RNA below 50 copies/ml and indinavir concentrations in hair but not in plasma, suggesting that hair concentrations gave more extensive information on drug exposure than a single plasma sample.
aServices des Maladies Infectieuses et Tropicales
bd'Epidémiologie, Biostatistique et Recherche Clinique
cde Pharmacie Clinique
eInserm U 798; APHP, Hôpital Bichat Claude Bernard, Paris, France
fUniversité Denis Diderot, Paris 7, France.
Received 7 July, 2006
Accepted 15 September, 2006