Hair versus plasma concentrations as indicator of indinavir exposure in HIV-1-infected patients treated with indinavir/ritonavir combination

Duval, Xaviera,b,e,f; Peytavin, Gillesc; Breton, Guillaumea; Ecobichon, Jean-Luca; Descamps, Dianed,f; Thabut, Gabrielb; Leport, Catherinea,f

AIDS:
doi: 10.1097/QAD.0b013e3280118486
Research Letters
Abstract

Large intra-individual variability in plasma levels may limit the interest of therapeutic drug monitoring based on a single determination. Indinavir concentrations were determined both in plasma and hair samples, and correlated with concomitant plasma HIV-RNA in 43 HIV-infected patients. In multivariate analysis, significant association was found between HIV-RNA below 50 copies/ml and indinavir concentrations in hair but not in plasma, suggesting that hair concentrations gave more extensive information on drug exposure than a single plasma sample.

Author Information

aServices des Maladies Infectieuses et Tropicales

bd'Epidémiologie, Biostatistique et Recherche Clinique

cde Pharmacie Clinique

dde Virologie

eInserm U 798; APHP, Hôpital Bichat Claude Bernard, Paris, France

fUniversité Denis Diderot, Paris 7, France.

Received 7 July, 2006

Accepted 15 September, 2006

© 2007 Lippincott Williams & Wilkins, Inc.