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Influence of pravastatin on carotid artery structure and function in dyslipidemic HIV-infected patients receiving antiretroviral therapy

Boccara, Francka; Simon, Tabassomeb; Lacombe, Karinec; Cohen, Arield; Laloux, Brigittea; Bozec, Erwana; Durant, Stéphanieb; Girard, Pierre-Mariec; Laurent, Stéphanea; Boutouyrie, Pierrea

doi: 10.1097/QAD.0b013e32801120e3
Research Letters

Forty-two pravastatin-treated HIV-positive patients and 42 sex, age, and smoking status-matched hypercholesterolemic HIV-positive patients not under lipid-lowering treatment were compared for differences in intima-media thickness (IMT) of the common carotid artery (CCA) and aortic stiffness. Pravastatin had no influence on carotid artery structure and function, or aortic stiffness. Age and body mass index were independent determinants of IMT of the CCA. Mean arterial pressure, age, duration of HIV infection and protease inhibitor exposure determined aortic stiffness.

aDepartment of Pharmacology, Université Paris-Descartes, Faculté de Médecine, INSERM 652, Hôpital Européen Georges Pompidou, Paris, France

bDepartments of Pharmacology and URC-EST

cInfectious Diseases

dCardiology, Saint Antoine University Hospital, Assistance Publique Hôpitaux de Paris, Université Paris-VI, Paris, France.

© 2006 Lippincott Williams & Wilkins, Inc.