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High levels of cervical HIV-1 RNA during early HIV-1 infection

Lavreys, Ludoa,b; Baeten, Jared Ma; Panteleeff, Dana Dc; Richardson, Barbra Aa,c; McClelland, R Scotta,b; Chohan, Varshab; Mandaliya, Kishorchandrad; Ndinya-Achola, Jeckoniah Ob; Overbaugh, Juliec

doi: 10.1097/QAD.0b013e328010f1e7
Research Letters

Few data are available on genital tract viral replication early after HIV-1 acquisition, when infectivity is high. We compared cervical HIV-1 RNA from 60 women with paired samples from within 90 days after HIV-1 acquisition and at viral setpoint (4–24 months). Cervical HIV-1 was higher in early compared with setpoint samples (mean 3.43 versus 2.85 log10 copies/swab, P < 0.001). After adjusting for HIV-1-plasma RNA, cervical HIV-1 RNA from 30 days or less after infection was increased by 0.45 log10 copies/swab (P = 0.006).

aDepartments of Epidemiology, Medicine, and Biostatistics, University of Washington, Seattle, Washington, USA

bDepartment of Medical Microbiology, University of Nairobi, Nairobi, Kenya

cDivisions of Human Biology and Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA

dCoast General Provincial Hospital, Mombasa, Kenya.

Received 25 July, 2006

Accepted 15 September, 2006

© 2006 Lippincott Williams & Wilkins, Inc.