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Persistence of a sexually transmitted highly resistant HIV-1: pol quasispecies evolution over 33 months in the absence of treatment

Neifer, Stefana; Somogyi, Sybilleb; Schlote, Frankc; Berg, Thomasa; Poggensee, Gabrieleb; Kuecherer, Claudiab

doi: 10.1097/QAD.0b013e328010ac6f
Research Letters

The evolution of a sexually transmitted multiresistant HIV-1 in a linked transmission chain was followed for 33 months to assess its potential to persist in the absence of treatment. The multiresistant HIV reverted slowly to wild type in reverse transcriptase (positions 44, 67, 74, 118) rendering the virus only susceptible to lamivudine/emtricitabine. Persistence of the replication-competent resistant HIV increases its potential to spread further and strengthens the importance of resistance testing in newly infected patients.

aMedical Laboratory Prenzlauer Berg, Berlin, Germany

bRobert Koch Institut, Berlin, Germany

cDr Schlote and colleagues medical practice, Berlin, Germany

Received 25 May, 2006

Revised 29 August, 2006

Accepted 8 September, 2006

© 2006 Lippincott Williams & Wilkins, Inc.