Skip Navigation LinksHome > November 14, 2006 - Volume 20 - Issue 17 > Nevirapine versus efavirenz in 742 patients: no link of live...
doi: 10.1097/QAD.0b013e3280110cae
Research Letters

Nevirapine versus efavirenz in 742 patients: no link of liver toxicity with female sex, and a baseline CD4 cell count greater than 250 cells/μl

Manfredi, Roberto; Calza, Leonardo

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Recent studies have reported increased nevirapine hepatotoxicity in female patients with CD4 lymphocyte counts greater than 250 cells/μl (especially pregnant women). However, our open-label comparison of 742 patients treated with either nevirapine or efavirenz-based HAART as naive patients, experienced subjects, or patients on salvage therapy, found no increased hepatotoxicity in nevirapine-treated subjects, in particular with regard to both sex (females versus males) and T-cell-mediated immunodeficiency (CD4 cell counts above versus below 250 cells/μl).

© 2006 Lippincott Williams & Wilkins, Inc.


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