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A novel hepatitis B virus mutation with resistance to adefovir but not to tenofovir in an HIVhepatitis B virus-co-infected patient

Lacombe, Karinea,b,c; Ollivet, Aurélied; Gozlan, Joelc,e; Durantel, Sandrad; Tran, Nathalief; Girard, Pierre-Marieb,c; Zoulim, Fabiend,g

doi: 10.1097/01.aids.0000252061.35422.84
Research Letters

A molecular virology analysis performed in an HIV–hepatitis B virus (HBV) co-infected patient showed the emergence of an unusual HBV polymerase gene mutation (rt A181T) under adefovir therapy, conferring resistance to adefovir but not to tenofovir, as proved by in-vitro phenotypic analysis. This observation suggests that careful monitoring of co-infected patients is required to diagnose HBV resistance to nucleos(t)ide analogues, and that tenofovir may be active at least against some of the adefovir-resistant strains.

aInserm, U707, Epidémiologie, Systèmes d'informations, Modélisation, Paris, F-75012 France

bUniversité Pierre et Marie Curie, Paris, F-75012 France

cAP HP, Hôpital Saint-Antoine, Service de Maladies Infectieuses et Tropicales, Paris, F-75012 France

dInserm, U271, Laboratoire des virus hépatiques et pathologies associées, Lyon, F-69000 France

eUMR 7079, Université Pierre et Marie Curie, Centre de Recherche des Cordeliers, F-75005 Paris, France

fLaboratoire Biomérieux, Marcy-L'Etoile, France

gHospices Civils de Lyon, Hôpital de l'Hôtel-Dieu, Service d'Hépatologie, Lyon, F-69288 France.

Received 27 May, 2005

Revised 23 June, 2005

Accepted 11 August, 2005

© 2006 Lippincott Williams & Wilkins, Inc.