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IL-1 gene polymorphism and periodontal status of HIV Brazilians on highly active antiretroviral therapy

de S Gonçalves, Lucioa; Ferreira, Sônia Maria Sb; Souza, Celso Ob; Colombo, Ana Paula Va

doi: 10.1097/01.aids.0000242826.97495.7c
Research Letters

A genotype in the IL-1 gene cluster is associated with an increased risk of periodontitis. We investigated whether polymorphisms in the IL-1A +4845 and IL-1B +3954 loci affect the periodontal status of HIV-infected Brazilians on HAART. HIV-positive and HIV-negative subjects with periodontitis were genotyped for IL-1 by polymerase chain reaction and restriction enzyme digestion. Only 11.4% of patients were genotype positive. No associations between genotype positivity and HIV infection or periodontal status were found in this population.

aInstitute of Microbiology, Brazil

bDental School of the Federal University of Rio de Janeiro, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.

Received 21 March, 2006

Accepted 18 May, 2006

© 2006 Lippincott Williams & Wilkins, Inc.